A Photoswitchable Chalcone-Carbohydrate Conjugate Obtained by CuAAC Click Reaction

Flavylium/Chalcone-based molecular switches comprise features such as pH-gated photochromism and fluorescence properties that make them attractive for many applications, ranging from stimuli-responsive materials to photopharmacology. However, in contrast other common photoswitches, the application of flavylium compounds these areas remains largely unexplored. Among possible reasons, this may be due lack general strategies attach molecules substrates polymers, nanoparticles, biomolecules, or surfaces. In work, we have shown a copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) can employed obtain chalcone conjugate. We used an isosorbide carbohydrate demonstrate strategy investigated photochemical chalcone-isosorbide The obtained results show new compound are similar equivalent flavylium/chalcone confirming feasibility conjugation strategy.